Researchers at the Cleveland Clinic have treated cancer in dogs, and this may lead to a new strategy on how to fight cancer in people as well.
Joseph A. Bauer, PhD at the 237th national meeting of the American Chemical Society, presented research on just this topic. The research built on more than 60 years of effort toward developing a B12 based attack for cancer.
The story begins with a "miracle dog" by the name of Oscar, a ten year old Bichon Frise who had a very aggressive type of cancer known as anal sac adenocarcinoma.
After the standard chemotherapy and radiation, and with no improvement, poor Oscar was left unable to walk and with only three months to live.
As a last hope, Bauer and his colleagues gave the super sick pooch a cancer killing medicine known as nitrosylcobalamin (NO-Cbl for short).
Within 14 days Oscars cancer had improved significantly and he was back on his feet again.
This compound has now been given to other dogs with equally promising results and no negative side effects. This drug targets cancer cells like a "Trojan horse", delivered by being hidden inside something that looks harmless or beneficial.
The compound is made with nitric oxide that's attached to vitamin B12. Researchers know that receptors on the cancer cell surfaces will attract the vitamin and so help it getting into the cell.
The compound works because cancer cells have extra B12 receptors. Once inside, the nitric oxide is released and the cell dies. Genius, pure genius.
Bauer's team is using ultrasound and MRI imaging to keep an eye on tumor size in all three of the dogs currently under treatment.
After 9 months of NO-Cbl the spinal tumor of a 6 year old golden retriever, Buddy, has been reduced by 40%, and the inoperable thyroid cancer of a 13 year old female giant schnauzer by 77% in just ten weeks of treatment.
Also, Haley, a golden retriever, is being treated for a spinal tumor. Once the team treats ten dogs with the drug, they'll go for FDA approval to test the medication in people.
Mice aren't the only good subjects to use for such research.
He points out that people and dogs are genetically similar - enough to make a successful case for approval from the FDA.
Interesting to know that the National Cancer Institute has data on pets.
After all, they breathe the same air as we do; drink the same water as we do and eat processed foods just as we do.
"We are one of the few research groups that is offering to treat dogs with cancer that otherwise have no hope," Bauer makes clear. "With no other options available, most people in this situation opt to euthanize so that their pets don't go through the pain of disease and trauma of surgery."
The good news for dog owners is that this treatment also offers hope for a faithful friend who may be one of the estimated 6 million dogs in the U.S. alone diagnosed with cancer each year.
It's a rare thing for research to uncover a treatment that can be used for animals, and yet holds realistic promise for people as well.
Next - just head on over to the Daily Health Bulletin for more information on how to fight cancer, plus for a limited time get 5 free fantastic health reports. Click here for the automated video on this study on how to fight cancer.
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